I agree, there's no golden rule. Just make sure the text is readable and you've got certain things to consider such as the DDA. A lot of web designers seem to forget that nowadays.
The trouble is you are very restricted on the space for mobiles and keeping the site usable.
I stay away from Bootstrap and do everything bespoke and independently for each web design we build.
For me, Mockups are an import part of the process. It depends on how your company works and flexible you are with changes. You could have an agreed stage where any drastic changes after a restrcited.
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