Wouldn't it depend on the compression settings in the PDF? Also maybe constructing the artwork set at the respective sizes they will be used.
Depending on what software your using, changing the settings in the PDF set-up menu can help quite a lot. It may add to the file size but if that's what he wants, that's the price he has to pay! (I love Fireworks for crunching down file's, it has lots of tools for controlling quality)
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